CATH Classification

Domain Context

CATH Clusters

Superfamily 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family Phosphodiesterase 9A

Enzyme Information

3.1.4.35
3',5'-cyclic-GMP phosphodiesterase.
based on mapping to UniProt O76083
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.

UniProtKB Entries (1)

O76083
PDE9A_HUMAN
Homo sapiens
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

PDB Structure

PDB 3QI4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural asymmetry of phosphodiesterase-9, potential protonation of a glutamic Acid, and role of the invariant glutamine.
Hou, J., Xu, J., Liu, M., Zhao, R., Luo, H.B., Ke, H.
Plos One