CATH Domain 3pdbD02

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.640	Aspartate Aminotransferase; domain 2
	3.40.640.10	Type I PLP-dependent aspartate aminotransferase-like (Major domain)

Domain Context

CATH Clusters

Superfamily	Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family	Aspartate aminotransferase

Enzyme Information

2.6.1.1	Aspartate transaminase. based on mapping to UniProt P05202 L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate. -!- Also acts on L-tyrosine, L-phenylalanine and L-tryptophan. -!- This activity can be formed from EC 2.6.1.57 by controlled proteolysis.
2.6.1.7	Kynurenine--oxoglutarate transaminase. based on mapping to UniProt P05202 L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate. -!- Also acts on 3-hydroxykynurenine. -!- The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.

UniProtKB Entries (1)

AATM_MOUSE

Mus musculus

Aspartate aminotransferase, mitochondrial

PDB Structure

PDB	3PDB
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Biochemical and structural characterization of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV. Han, Q., Robinson, H., Cai, T., Tagle, D.A., Li, J. Biosci.Rep.