CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Adenosylhomocysteinase

Enzyme Information

3.3.1.1
Adenosylhomocysteinase.
based on mapping to UniProt Q9SP37
S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine.
-!- The NAD(+) cofactor appears to bring about a transient oxidation at C-3' of the 5'-deoxyadenosine residue, thus labilizing the thioether bond cf. EC 5.5.1.4.

UniProtKB Entries (1)

Q9SP37
SAHH_LUPLU
Lupinus luteus
Adenosylhomocysteinase

PDB Structure

PDB 3ONF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
High-resolution structures of complexes of plant S-adenosyl-L-homocysteine hydrolase (Lupinus luteus).
Brzezinski, K., Dauter, Z., Jaskolski, M.
Acta Crystallogr.,Sect.D