CATH Classification
Domain Context
CATH Clusters
Superfamily | Methyltransferase, Cobalt-precorrin-4 Transmethylase; Domain 2 |
Functional Family |
Enzyme Information
2.1.1.133 |
Precorrin-4 C(11)-methyltransferase.
based on mapping to UniProt O68100
S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin-5.
-!- In the aerobic cobalamin biosythesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A. -!- The first of the four steps is carried out by EC 1.14.13.83 (CobG), yielding precorrin-3B as the product. -!- This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; EC 2.1.1.131), C-11 (CobM; 2.1.1.133) and C-1 (CobF; EC 2.1.1.152) of the macrocycle, giving rise to precorrin- 4, precorrin-5 and precorrin-6A, respectively.
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UniProtKB Entries (1)
O68100 |
COBM_RHOCB
Rhodobacter capsulatus SB 1003
Precorrin-4 C(11)-methyltransferase
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PDB Structure
PDB | 3NDC |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Crystal structure of Precorrin-4 C11-methyltransferase from Rhodobacter capsulatus
To be Published
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