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1 keywords

CATH Domain 3lwbB03

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.1490 Dna Ligase; domain 1
Homologous Superfamily 3.30.1490.20 ATP-grasp fold, A domain

Domain Context

CATH Clusters

Superfamily ATP-grasp fold, A domain
Functional Family D-alanine--D-alanine ligase

Enzyme Information

6.3.2.4
D-alanine--D-alanine ligase.
based on mapping to UniProt P9WP31
ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.
-!- Involved with EC 6.3.2.7 or EC 6.3.2.13, EC 6.3.2.8, EC 6.3.2.9 and EC 6.3.2.10 in the synthesis of a cell-wall peptide.

UniProtKB Entries (1)

P9WP31
DDL_MYCTU
Mycobacterium tuberculosis H37Rv
D-alanine--D-alanine ligase

PDB Structure

PDB 3LWB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of the Mycobacterium tuberculosis D-Alanine:D-Alanine Ligase, a Target of the Antituberculosis Drug D-Cycloserine.
Bruning, J.B., Murillo, A.C., Chacon, O., Barletta, R.G., Sacchettini, J.C.
Antimicrob.Agents Chemother.
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