CATH Domain 3l9xB01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Glutathione-regulated potassium-efflux system protein KefB

Enzyme Information

1.6.5.2

NAD(P)H dehydrogenase (quinone).

based on mapping to UniProt P0A754

NAD(P)H + a quinone = NAD(P)(+) + a hydroquinone.

-!- The enzyme catalyzes a two-electron reduction and has a preference for short-chain acceptor quinones, such as ubiquinone, benzoquinone, juglone and duroquinone. -!- The animal, but not the plant, form of the enzyme is inhibited by dicoumarol. -!- Formerly EC 1.6.99.2.

UniProtKB Entries (1)

P0A754

KEFF_ECOLI

Escherichia coli K-12

Glutathione-regulated potassium-efflux system ancillary protein KefF

PDB Structure

PDB	3L9X
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Mechanism of ligand-gated potassium efflux in bacterial pathogens. Roosild, T.P., Castronovo, S., Healy, J., Miller, S., Pliotas, C., Rasmussen, T., Bartlett, W., Conway, S.J., Booth, I.R. Proc.Natl.Acad.Sci.USA

Network disruptions