CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family DNA helicase

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt P29469
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

P53091
MCM6_YEAST
Saccharomyces cerevisiae S288C
DNA replication licensing factor MCM6

PDB Structure

PDB 3JA8
External Links
Method ELECTRON MICROSCOPY
Organism
Primary Citation
Structure of the eukaryotic MCM complex at 3.8 angstrom
Li, N., Zhai, Y., Zhang, Y., Li, W., Yang, M., Lei, J., Tye, B.K., Gao, N.
Nature