CATH Classification

Domain Context

CATH Clusters

Superfamily DD-peptidase/beta-lactamase superfamily
Functional Family Beta-lactamase

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt P00811
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P00811
AMPC_ECOLI
Escherichia coli K-12
Beta-lactamase

PDB Structure

PDB 3IXH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural bases for stability-function tradeoffs in antibiotic resistance.
Thomas, V.L., McReynolds, A.C., Shoichet, B.K.
J.Mol.Biol.