CATH Classification

Domain Context

CATH Clusters

Superfamily Cysteine proteinases
Functional Family Cathepsin S

Enzyme Information

3.4.22.43
Cathepsin V.
based on mapping to UniProt O60911
The recombinant enzyme hydrolyzes proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val- Arg-NHMec).
-!- Maximally active at pH 5.7 and unstable at neutral pH. -!- Compound E-64, leupeptin and chicken cystatin are inhibitors. -!- Belongs to peptidase family C1.

UniProtKB Entries (2)

O60911
CATL2_HUMAN
Homo sapiens
Cathepsin L2
Q3Y9I6
CLIT5_CLINE
Clitocybe nebularis
Clitocypin-5

PDB Structure

PDB 3H6S
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Versatile loops in mycocypins inhibit three protease families.
Renko, M., Sabotic, J., Mihelic, M., Brzin, J., Kos, J., Turk, D.
J.Biol.Chem.