CATH Domain 3gtyX03

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.3120	Trigger factor, domain 2
	1.10.3120.10	Trigger factor, C-terminal domain

Domain Context

CATH Clusters

Superfamily	Trigger factor, C-terminal domain
Functional Family	Trigger factor

Enzyme Information

5.2.1.8

Peptidylprolyl isomerase.

based on mapping to UniProt Q9WZF8

Peptidylproline (omega=180) = peptidylproline (omega=0).

-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q9WZF8

TIG_THEMA

Thermotoga maritima MSB8

Trigger factor

PDB Structure

PDB	3GTY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Promiscuous substrate recognition in folding and assembly activities of the trigger factor chaperone Martinez-Hackert, E., Hendrickson, W.A. Cell(Cambridge,Mass.)