CATH Classification

Domain Context

CATH Clusters

Superfamily Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
Functional Family PC4 and SFRS1-interacting protein-like isoform X1

Enzyme Information

UniProtKB Entries (2)

P04584
POL_HV2RO
Human immunodeficiency virus type 2 (ISOLATE ROD)
Gag-Pol polyprotein
O75475
PSIP1_HUMAN
Homo sapiens
PC4 and SFRS1-interacting protein

PDB Structure

PDB 3F9K
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A novel co-crystal structure affords the design of gain-of-function lentiviral integrase mutants in the presence of modified PSIP1/LEDGF/p75
Hare, S., Shun, M.C., Gupta, S.S., Valkov, E., Engelman, A., Cherepanov, P.
Plos Pathog.