CATH Classification

Domain Context

CATH Clusters

Superfamily Cytochrome P450
Functional Family Allene oxide synthase, chloroplastic

Enzyme Information

4.2.1.92
Hydroperoxide dehydratase.
based on mapping to UniProt Q96242
(9Z,11E,15Z)-(13S)-hydroperoxyoctadeca-9,11,15-trienoate = (9Z,15Z)- (13S)-12,13-epoxyoctadeca-9,11,15-trienoate + H(2)O.
-!- Acts on a number of unsaturated fatty-acid hydroperoxides, forming the corresponding allene oxides. -!- The product of the above reaction is unstable and is acted upon by EC 5.3.99.6 to form the cyclopentenone derivative (15Z)-12-oxophyto- 10,15-dienoate (OPDA), which is the first cyclic and biologically active metabolite in the jasmonate biosynthesis pathway.

UniProtKB Entries (1)

Q96242
CP74A_ARATH
Arabidopsis thaliana
Allene oxide synthase, chloroplastic

PDB Structure

PDB 3DSK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural insights into the evolutionary paths of oxylipin biosynthetic enzymes
Lee, D.S., Nioche, P., Hamberg, M., Raman, C.S.
Nature