CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.238 | Recoverin; domain 1 | |
1.10.238.10 | EF-hand |
Domain Context
CATH Clusters
Superfamily | EF-hand |
Functional Family | calpain-2 catalytic subunit |
Enzyme Information
3.4.22.53 |
Calpain-2.
based on mapping to UniProt Q07009
Broad endopeptidase specificity.
-!- Cytosolic in animal cells. -!- The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.52. -!- Belongs to peptidase family C2. -!- Formerly EC 3.4.22.17 and EC 3.4.24.5.
|
UniProtKB Entries (1)
Q07009 |
CAN2_RAT
Rattus norvegicus
Calpain-2 catalytic subunit
|
PDB Structure
PDB | 3DF0 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains.
Nature
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