CATH Domain 3c43B01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1820	alpha/beta hydrolase

Domain Context

CATH Clusters

Superfamily	alpha/beta hydrolase
Functional Family	Dipeptidyl peptidase 4

Enzyme Information

3.4.14.5

Dipeptidyl-peptidase IV.

based on mapping to UniProt P27487

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

-!- A membrane-bound serine-type peptidase in mammals. -!- EC 3.4.14.11 catalyzes a similar reaction. -!- Belongs to peptidase family S9B.

UniProtKB Entries (1)

P27487

DPP4_HUMAN

Homo sapiens

Dipeptidyl peptidase 4

PDB Structure

PDB	3C43
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Spodoptera
Primary Citation	Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors Edmondson, S.D., Wei, L., Xu, J., Shang, J., Xu, S., Pang, J., Chaudhary, A., Dean, D.C., He, H., Leiting, B., Lyons, K.A., Patel, R.A., Patel, S.B., Scapin, G., Wu, J.K., Beconi, M.G., Thornberry, N.A., Weber, A.E. Bioorg.Med.Chem.Lett.