CATH Domain 3c0aA00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.572	Thymidylate Synthase; Chain A
	3.30.572.10	Thymidylate synthase/dCMP hydroxymethylase domain

Domain Context

CATH Clusters

Superfamily	Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family

Enzyme Information

2.1.1.45

Thymidylate synthase.

based on mapping to UniProt P00469

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

UniProtKB Entries (1)

TYSY_LACCA

Lactobacillus casei

Thymidylate synthase

PDB Structure

PDB	3C0A
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening Mangani, S., Cancian, L., Leone, R., Pozzi, C., Lazzari, S., Luciani, R., Ferrari, S., Costi, M.P. J.Med.Chem.