CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.300 | P-loop containing nucleotide triphosphate hydrolases |
Domain Context
CATH Clusters
| Superfamily | P-loop containing nucleotide triphosphate hydrolases |
| Functional Family | Fidgetin-like 1 |
Enzyme Information
| 5.6.1.1 |
Microtubule-severing ATPase.
based on mapping to UniProt Q8I0P1
n ATP + n H(2)O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.
-!- A member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome. -!- Formerly EC 3.6.4.3.
|
UniProtKB Entries (1)
| Q8I0P1 |
SPAST_DROME
Drosophila melanogaster
Spastin
|
PDB Structure
| PDB | 3B9P |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin.
Nature
|
