CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Vascular endothelial growth factor receptor 2

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P35968
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P35968
VGFR2_HUMAN
Homo sapiens
Vascular endothelial growth factor receptor 2

PDB Structure

PDB 3B8R
External Links
Method X-RAY DIFFRACTION
Organism Trichoplusia
Primary Citation
Evaluation of a Series of Naphthamides as Potent, Orally Active Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase Inhibitors
Weiss, M.M., Harmange, J.C., Polverino, A.J., Bauer, D., Berry, L., Berry, V., Borg, G., Bready, J., Chen, D., Choquette, D., Coxon, A., DeMelfi, T., Doerr, N., Estrada, J., Flynn, J., Graceffa, R.F., Harriman, S.P., Kaufman, S., La, D.S., Long, A., Neervannan, S., Patel, V.F., Potashman, M., Regal, K., Roveto, P.M., Schrag, M.L., Starnes, C., Tasker, A., Teffera, Y., Whittington, D.A., Zanon, R.
J.Med.Chem.