CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.40 | Beta Barrel | |
2.40.128 | Lipocalin | |
2.40.128.390 |
Domain Context
CATH Clusters
Superfamily | 2.40.128.390 |
Functional Family |
Enzyme Information
2.4.99.21 |
Dolichyl-phosphooligosaccharide-protein glycotransferase.
based on mapping to UniProt Q8U4D2
An archaeal dolichyl phosphooligosaccharide + [protein]-L-asparagine = an archaeal dolichyl phosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine.
-!- The enzyme, characterized from the archaea Methanococcus voltae and Haloferax volcanii, transfers a glycan component from dolichyl phosphooligosaccharide to external proteins. -!- It is different from EC 2.4.99.18 which uses dolichyl diphosphate as carrier compound in bacteria and eukaryotes. -!- The enzyme participates in the N-glycosylation of proteins in some archaea. -!- Dolichol used by archaea is different from that used by eukaryotes; it is much shorter (C(55)-C(60)), it is alpha,omega-saturated and it may have additional unsaturated positions in the chain.
|
UniProtKB Entries (1)
Q8U4D2 |
AGLB1_PYRFU
Pyrococcus furiosus DSM 3638
Dolichyl-phosphooligosaccharide-protein glycotransferase 1
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PDB Structure
PDB | 2ZAG |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Structure-guided identification of a new catalytic motif of oligosaccharyltransferase
Embo J.
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