CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.489 | Chloroperoxidase | |
1.10.489.10 | Chloroperoxidase-like |
Domain Context
CATH Clusters
Superfamily | Chloroperoxidase-like |
Functional Family | Aromatic peroxygenase |
Enzyme Information
1.11.2.1 |
Unspecific peroxygenase.
based on mapping to UniProt B9W4V6
RH + H(2)O(2) = ROH + H(2)O.
-!- Enzymes of this type include glycoproteins secreted by agaric basidiomycetes. -!- They catalyze the insertion of an oxygen atom from H(2)O(2) into a wide variety of substrates, including aromatic rings such as naphthalene, toluene, phenanthrene, pyrene and p-nitrophenol, recalcitrant heterocycles such as pyridine, dibenzofuran, various ethers (resulting in O-dealkylation) and alkanes such as propane, hexane and cyclohexane. -!- Reactions catalyzed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, O- and N-dealkylation, bromination and one-electron oxidations. -!- They have little or no activity toward chloride. -!- Mechanistically, the catalytic cycle of unspecific (mono)- peroxygenases combines elements of the 'shunt' pathway of cytochrome P450s (a side activity that utilizes a peroxide in place of dioxygen and NAD(P)H) and the classic heme peroxidase cycle.
|
UniProtKB Entries (1)
B9W4V6 |
APO1_AGRAE
Agrocybe aegerita
Aromatic peroxygenase
|
PDB Structure
PDB | 2YP1 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structural Basis of Substrate Conversion in a New Aromatic Peroxygenase: P450 Functionality with Benefits
J.Biol.Chem.
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