CATH Domain 2wwrD01

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Glyoxylate reductase/hydroxypyruvate reductase b

Enzyme Information

1.1.1.79	Glyoxylate reductase (NADP(+)). based on mapping to UniProt Q9UBQ7 Glycolate + NADP(+) = glyoxylate + NADPH. -!- Also reduces hydroxypyruvate to glycerate. -!- Has some affinity for NAD(+).
1.1.1.81	Hydroxypyruvate reductase. based on mapping to UniProt Q9UBQ7 D-glycerate + NAD(P)(+) = hydroxypyruvate + NAD(P)H.

UniProtKB Entries (1)

GRHPR_HUMAN

Homo sapiens

Glyoxylate reductase/hydroxypyruvate reductase

PDB Structure

PDB	2WWR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural Basis of Substrate Specificity in Human Glyoxylate Reductase/Hydroxypyruvate Reductase. Booth, M.P., Conners, R., Rumsby, G., Brady, R.L. J.Mol.Biol.