CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.40 | Beta Barrel | |
2.40.100 | Cyclophilin | |
2.40.100.10 | Cyclophilin-like |
Domain Context
CATH Clusters
Superfamily | Cyclophilin-like |
Functional Family | Peptidyl-prolyl cis-trans isomerase G |
Enzyme Information
5.2.1.8 |
Peptidylprolyl isomerase.
based on mapping to UniProt Q13427
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.
|
UniProtKB Entries (1)
Q13427 |
PPIG_HUMAN
Homo sapiens
Peptidyl-prolyl cis-trans isomerase G
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PDB Structure
PDB | 2WFJ |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
The Thermodynamic Influence of Trapped Water Molecules on a Protein-Ligand Interaction.
Angew.Chem.Int.Ed.Engl.
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