CATH Classification

Domain Context

CATH Clusters

Superfamily FAD/NAD(P)-binding domain
Functional Family Glutathione reductase

Enzyme Information

1.8.1.12
Trypanothione-disulfide reductase.
based on mapping to UniProt P39051
Trypanothione + NADP(+) = trypanothione disulfide + NADPH.
-!- Trypanothione disulfide is the oxidized form of N(1),N(8)- bis(glutathionyl)-spermidine from the insect-parasitic trypanosomatid Crithidia fasciculata. -!- The activity is dependent on a redox-active cystine at the active center (cf. EC 1.8.1.7). -!- Formerly EC 1.6.4.8.

UniProtKB Entries (1)

P39051
TYTR_TRYBB
Trypanosoma brucei brucei
Trypanothione reductase

PDB Structure

PDB 2WBA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Comparative Structural, Kinetic and Inhibitor Studies of Trypanosoma Brucei Trypanothione Reductase with T. Cruzi.
Jones, D., Ariza, A., Chow, W.H.A., Oza, S.L., Fairlamb, A.H.
Mol.Biochem.Parasitol.