CATH Domain 2otxB02

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CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.30	Roll
	2.30.29	PH-domain like
	2.30.29.30	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Domain Context

CATH Clusters

Superfamily	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Functional Family	Putative src kinase-associated phosphoprotein 2

Enzyme Information

UniProtKB Entries (1)

SKAP2_MOUSE

Mus musculus

Src kinase-associated phosphoprotein 2

PDB Structure

PDB	2OTX
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	The Skap-hom dimerization and PH domains comprise a 3'-phosphoinositide-gated molecular switch. Swanson, K.D., Tang, Y., Ceccarelli, D.F., Poy, F., Sliwa, J.P., Neel, B.G., Eck, M.J. Mol.Cell