CATH Classification

Domain Context

CATH Clusters

Superfamily Aspartate Aminotransferase, domain 1
Functional Family dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase

Enzyme Information

2.6.1.106
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase.
based on mapping to UniProt Q9ZGH4
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2-oxoglutarate = dTDP-3- dehydro-4,6-deoxy-alpha-D-glucose + L-glutamate.
-!- The enzyme is involved in the biosynthesis of dTDP-alpha-D- desosamine, a sugar found in several bacterial macrolide antibiotics including erythromycin, megalomicin A, mycinamicin II, and oleandomycin. -!- The reaction occurs in the reverse direction.

UniProtKB Entries (1)

Q9ZGH4
DESV_STRVZ
Streptomyces venezuelae
DTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase

PDB Structure

PDB 2OGE
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Molecular architecture of DesV from Streptomyces venezuelae: A PLP-dependent transaminase involved in the biosynthesis of the unusual sugar desosamine.
Burgie, E.S., Thoden, J.B., Holden, H.M.
Protein Sci.