CATH Domain 2mutA00

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CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.150	DNA polymerase; domain 1
	1.10.150.20	5' to 3' exonuclease, C-terminal subdomain

Domain Context

CATH Clusters

Superfamily	5' to 3' exonuclease, C-terminal subdomain
Functional Family	DNA excision repair protein ERCC-1

Enzyme Information

UniProtKB Entries (1)

ERCC1_HUMAN

Homo sapiens

DNA excision repair protein ERCC-1

PDB Structure

PDB	2MUT
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism
Primary Citation	The Cerebro-oculo-facio-skeletal Syndrome Point Mutation F231L in the ERCC1 DNA Repair Protein Causes Dissociation of the ERCC1-XPF Complex. Faridounnia, M., Wienk, H., Kovacic, L., Folkers, G.E., Jaspers, N.G., Kaptein, R., Hoeijmakers, J.H., Boelens, R. J.Biol.Chem.