CATH Domain 2l5uA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.40	Herpes Virus-1
	3.30.40.10	Zinc/RING finger domain, C3HC4 (zinc finger)

Domain Context

CATH Clusters

Superfamily	Zinc/RING finger domain, C3HC4 (zinc finger)
Functional Family	chromodomain-helicase-DNA-binding protein 3 isoform X1

Enzyme Information

3.6.4.12

DNA helicase.

based on mapping to UniProt Q14839

ATP + H(2)O = ADP + phosphate.

-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

Q14839

CHD4_HUMAN

Homo sapiens

Chromodomain-helicase-DNA-binding protein 4

PDB Structure

PDB	2L5U
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism
Primary Citation	Plant Homeodomain (PHD) Fingers of CHD4 Are Histone H3-binding Modules with Preference for Unmodified H3K4 and Methylated H3K9 Mansfield, R.E., Musselman, C.A., Kwan, A.H., Oliver, S.S., Garske, A.L., Davrazou, F., Denu, J.M., Kutateladze, T.G., Mackay, J.P. J.Biol.Chem.