CATH Classification

Domain Context

CATH Clusters

Superfamily Single helix bin
Functional Family Ephrin type-A receptor 2

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P29317
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P29317
EPHA2_HUMAN
Homo sapiens
Ephrin type-A receptor 2

PDB Structure

PDB 2K9Y
External Links
Method SOLUTION NMR
Organism
Primary Citation
Left-Handed Dimer of EphA2 Transmembrane Domain: Helix Packing Diversity among Receptor Tyrosine Kinases
Bocharov, E.V., Mayzel, M.L., Volynsky, P.E., Mineev, K.S., Tkach, E.N., Ermolyuk, Y.S., Schulga, A.A., Efremov, R.G., Arseniev, A.S.
Biophys.J.