CATH Domain 2j0xB04

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.70	Alpha-Beta Plaits
	3.30.70.260	ACT domain

Domain Context

CATH Clusters

Superfamily	3.30.70.260
Functional Family	Aspartokinase

Enzyme Information

2.7.2.4

Aspartate kinase.

based on mapping to UniProt P08660

ATP + L-aspartate = ADP + 4-phospho-L-aspartate.

-!- The enzyme from Escherichia coli is a multifunctional protein, which also catalyzes the reaction of EC 1.1.1.3. -!- This is also the case for two of the four isoenzymes in Arabidopsis thaliana. -!- The equilibrium constant strongly favors the reaction from right to left, i.e. the non-physiological direction of reaction.

UniProtKB Entries (1)

P08660

AK3_ECOLI

Escherichia coli K-12

Lysine-sensitive aspartokinase 3

PDB Structure

PDB	2J0X
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structures of R- and T-State Escherichia Coli Aspartokinase III: Mechanisms of the Allosteric Transition and Inhibition by Lysine. Kotaka, M., Ren, J., Lockyer, M., Hawkins, A.R., Stammers, D.K. J.Biol.Chem.

Network disruptions