CATH Classification

Domain Context

CATH Clusters

Superfamily Glycoside hydrolase 38, N terminal domain
Functional Family Alpha-mannosidase

Enzyme Information
Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase.
based on mapping to UniProt Q24451
Man(5)GlcNAc(3)-[protein] + 2 H(2)O = Man(3)GlcNAc(3)-[protein] + 2 alpha-D-mannopyranose.
-!- The enzyme, found in plants and animals, participates in the processing of N-glycans in the Golgi apparatus. -!- It removes two mannosyl residues, one linked by alpha-1,3 linkage, and the other linked by alpha-1,6 linkage, both of which are removed by the same catalytic site. -!- The enzyme is sensitive to swainsonine.

UniProtKB Entries (1)

Drosophila melanogaster
Alpha-mannosidase 2

PDB Structure

PDB 2F18
External Links
Organism Drosophila
Primary Citation
Evaluation of docking programs for predicting binding of Golgi alpha-mannosidase II inhibitors: a comparison with crystallography.
Englebienne, P., Fiaux, H., Kuntz, D.A., Corbeil, C.R., Gerber-Lemaire, S., Rose, D.R., Moitessier, N.