CATH Classification

Domain Context

CATH Clusters

Superfamily 5' to 3' exonuclease, C-terminal subdomain
Functional Family DNA polymerase iota

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt Q9UNA4
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

Q9UNA4
POLI_HUMAN
Homo sapiens
DNA polymerase iota

PDB Structure

PDB 2DPI
External Links
Method X-RAY DIFFRACTION
Organism Saccharomyces
Primary Citation
Hoogsteen base pair formation promotes synthesis opposite the 1,N(6)-ethenodeoxyadenosine lesion by human DNA polymerase iota.
Nair, D.T., Johnson, R.E., Prakash, L., Prakash, S., Aggarwal, A.K.
Nat.Struct.Mol.Biol.