CATH Classification

Domain Context

CATH Clusters

Superfamily Cyclophilin-like
Functional Family Peptidylprolyl isomerase domain and WD repeat-containing 1

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt Q96BP3
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q96BP3
PPWD1_HUMAN
Homo sapiens
Peptidylprolyl isomerase domain and WD repeat-containing protein 1

PDB Structure

PDB 2A2N
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The crystal structure of human WD40 repeat-containing peptidylprolyl isomerase (PPWD1).
Davis, T.L., Walker, J.R., Ouyang, H., MacKenzie, F., Butler-Cole, C., Newman, E.M., Eisenmesser, E.Z., Dhe-Paganon, S.
Febs J.