CATH Domain 1z68B02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1820	alpha/beta hydrolase

Domain Context

CATH Clusters

Superfamily	alpha/beta hydrolase
Functional Family	Dipeptidyl peptidase 4

Enzyme Information

3.4.21.-	Serine endopeptidases. based on mapping to UniProt Q12884
3.4.14.5	Dipeptidyl-peptidase IV. based on mapping to UniProt Q12884 Release of an N-terminal dipeptide, Xaa-Yaa-\|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline. -!- A membrane-bound serine-type peptidase in mammals. -!- EC 3.4.14.11 catalyzes a similar reaction. -!- Belongs to peptidase family S9B.
3.4.21.26	Prolyl oligopeptidase. based on mapping to UniProt Q12884 Hydrolysis of Pro-\|-Xaa >> Ala-\|-Xaa in oligopeptides. -!- Found in vertebrates, plants and Flavobacterium. -!- Generally cytosolic, commonly activated by thiol compounds. -!- Belongs to peptidase family S9A. -!- Formerly EC 3.4.22.18.

UniProtKB Entries (1)

SEPR_HUMAN

Homo sapiens

Prolyl endopeptidase FAP

PDB Structure

PDB	1Z68
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Spodoptera
Primary Citation	Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein alpha. Aertgeerts, K., Levin, I., Shi, L., Snell, G.P., Jennings, A., Prasad, G.S., Zhang, Y., Kraus, M.L., Salakian, S., Sridhar, V., Wijnands, R., Tennant, M.G. J.Biol.Chem.