CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.20 | Alpha-Beta Barrel | |
3.20.20 | TIM Barrel | |
3.20.20.60 | Phosphoenolpyruvate-binding domains |
Domain Context
CATH Clusters
Superfamily | Phosphoenolpyruvate-binding domains |
Functional Family | 2-methylisocitrate lyase |
Enzyme Information
4.1.3.30 |
Methylisocitrate lyase.
based on mapping to UniProt P77541
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate.
-!- Acts on threo-D(s)-2-methylisocitrate, but not on threo-D(s)- isocitrate, threo-DL-isocitrate or erythro-L(s)-isocitrate.
|
UniProtKB Entries (1)
P77541 |
PRPB_ECOLI
Escherichia coli K-12
2-methylisocitrate lyase
|
PDB Structure
PDB | 1XG3 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Crystal Structures of 2-Methylisocitrate Lyase in Complex with Product and with Isocitrate Inhibitor Provide Insight into Lyase Substrate Specificity, Catalysis and Evolution
Biochemistry
|