CATH Classification

Domain Context

CATH Clusters

Superfamily HUPs
Functional Family NH(3)-dependent NAD(+) synthetase

Enzyme Information

6.3.1.5
NAD(+) synthase.
based on mapping to UniProt P18843
ATP + deamido-NAD(+) + NH(3) = AMP + diphosphate + NAD(+).
-!- L-glutamine also acts, more slowly, as amido-donor (cf. EC 6.3.5.1).

UniProtKB Entries (1)

P18843
NADE_ECOLI
Escherichia coli K-12
NH(3)-dependent NAD(+) synthetase

PDB Structure

PDB 1WXI
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structures of Escherichia coli NAD Synthetase with Substrates and Products Reveal Mechanistic Rearrangements
Jauch, R., Humm, A., Huber, R., Wahl, M.C.
J.Biol.Chem.