CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.40 | Immunoglobulin-like |
|
2.60.40.790 |
Domain Context
CATH Clusters
| Superfamily | 2.60.40.790 |
| Functional Family | ubiquitin carboxyl-terminal hydrolase 19 isoform X9 |
Enzyme Information
| 3.4.19.12 |
Ubiquitinyl hydrolase 1.
based on mapping to UniProt O94966
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.
|
UniProtKB Entries (1)
| O94966 |
UBP19_HUMAN
Homo sapiens
Ubiquitin carboxyl-terminal hydrolase 19
|
PDB Structure
| PDB | 1WH0 |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
Solution structure of the CS domain of human USP19
To be Published
|