CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.40 | Beta Barrel | |
2.40.100 | Cyclophilin | |
2.40.100.10 | Cyclophilin-like |
Domain Context
CATH Clusters
Superfamily | Cyclophilin-like |
Functional Family | Peptidyl-prolyl cis-trans isomerase |
Enzyme Information
5.2.1.8 |
Peptidylprolyl isomerase.
based on mapping to UniProt P14832
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.
|
UniProtKB Entries (1)
P14832 |
CYPH_YEAST
Saccharomyces cerevisiae S288C
Peptidyl-prolyl cis-trans isomerase
|
PDB Structure
PDB | 1VDN |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Crystal Structure Of Yeast Cyclophilin A Complexed With ACE-Ala-Ala-Pro-Ala-7-Amino-4-Methylcoumarin
to be published
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