CATH Classification

Domain Context

CATH Clusters

Superfamily Cyclophilin-like
Functional Family Peptidyl-prolyl cis-trans isomerase

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt P14832
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P14832
CYPH_YEAST
Saccharomyces cerevisiae S288C
Peptidyl-prolyl cis-trans isomerase

PDB Structure

PDB 1VDN
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure Of Yeast Cyclophilin A Complexed With ACE-Ala-Ala-Pro-Ala-7-Amino-4-Methylcoumarin
Konno, M., Shibano, T., Okudaira, K., Takahashi, N.
to be published