CATH Domain 1uajA02
|1.10.1270||Trp Operon Repressor; Chain A|
|1.10.1270.20||tRNA(m1g37)methyltransferase, domain 2|
|Superfamily||tRNA(m1g37)methyltransferase, domain 2|
|Functional Family||tRNA (guanine-N(1)-)-methyltransferase|
based on mapping to UniProt P43912
S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.
-!- This enzyme is important for the maintenance of the correct reading frame during translation. -!- Unlike TrmD from Escherichia coli, which recognizes the G(36)pG(37) motif preferentially, the human enzyme (encoded by TRMT5) also methylates inosine at position 37. -!- Formerly EC 188.8.131.52.
UniProtKB Entries (1)
Haemophilus influenzae Rd KW20
Crystal structure of tRNA(m(1)G37)methyltransferase: insights into tRNA recognition