CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Protein Rep68

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt P03132
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

P03132
REP68_AAV2S
Adeno-associated virus 2 Srivastava/1982
Protein Rep68

PDB Structure

PDB 1U0J
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of adeno-associated virus type 2 Rep40-ADP complex: Insight into nucleotide recognition and catalysis by superfamily 3 helicases
James, J.A., Aggarwal, A.K., Linden, R.M., Escalante, C.R.
Proc.Natl.Acad.Sci.USA