CATH Domain 1rf8B01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.970	Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3
	1.20.970.30	eIF4G, eIF4E-binding domain

Domain Context

CATH Clusters

Superfamily	eIF4G, eIF4E-binding domain
Functional Family	Translation initiation factor eIF4G

Enzyme Information

UniProtKB Entries (1)

IF4E_YEAST

Saccharomyces cerevisiae S288C

Eukaryotic translation initiation factor 4E

PDB Structure

PDB	1RF8
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism	Escherichia
Primary Citation	Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E. Gross, J.D., Moerke, N.J., von der Haar, T., Lugovskoy, A.A., Sachs, A.B., McCarthy, J.E., Wagner, G. Cell(Cambridge,Mass.)