CATH Domain 1r8cA02
|3.30.460||Beta Polymerase; domain 2|
|3.30.460.10||Beta Polymerase, domain 2|
|Superfamily||Beta Polymerase, domain 2|
CCA tRNA nucleotidyltransferase.
based on mapping to UniProt O28126
A tRNA precursor + 2 CTP + ATP = a tRNA with a 3' CCA end + 3 diphosphate.
-!- The acylation of all tRNAs with an amino acid occurs at the terminal ribose of a 3' CCA sequence. -!- The CCA sequence is added to the tRNA precursor by stepwise nucleotide addition performed by a single enzyme that is ubiquitous in all living organisms. -!- Although the enzyme has the option of releasing the product after each addition, it prefers to stay bound to the product and proceed with the next addition. -!- Formerly EC 22.214.171.124 and EC 126.96.36.199.
UniProtKB Entries (1)
Archaeoglobus fulgidus DSM 4304
Crystal structures of an archaeal class I CCA-adding enzyme and its nucleotide complexes