CATH Classification

Domain Context

CATH Clusters

Superfamily Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Functional Family Methionine aminopeptidase 2

Enzyme Information
Methionyl aminopeptidase.
based on mapping to UniProt P50579
Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
-!- This membrane-bound enzyme, which is present in both prokaryotes and eukaryotes, releases the initiator methionine from nascent peptides. -!- The activity is dependent on the identity of the second, third and fourth amino acid residues of the target protein, but in general the enzyme acts only when the penultimate residue is small and uncharged (e.g. Gly, Ala, Cys, Ser, Thr, and Val). -!- Belongs to peptidase family M24A.

UniProtKB Entries (1)

Homo sapiens
Methionine aminopeptidase 2

PDB Structure

PDB 1R58
External Links
Primary Citation
3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2.
Sheppard, G.S., Wang, J., Kawai, M., BaMaung, N.Y., Craig, R.A., Erickson, S.A., Lynch, L., Patel, J., Yang, F., Searle, X.B., Lou, P., Park, C., Kim, K.H., Henkin, J., Lesniewski, R.