CATH Classification

Domain Context

CATH Clusters

Superfamily Urate Oxidase;
Functional Family Uricase

Enzyme Information
Factor independent urate hydroxylase.
based on mapping to UniProt Q00511
Urate + O(2) + H(2)O = 5-hydroxyisourate + H(2)O(2).
-!- Was previously thought to be a copper protein, but it is now known that the enzymes from soybean (Glycine max), the mold Aspergillus flavus and Bacillus subtilis contains no copper nor any other transition-metal ion. -!- The 5-hydroxyisourate formed decomposes spontaneously to form allantoin and CO(2), although there is an enzyme-catalyzed pathway in which EC catalyzes the first step. -!- The enzyme is different from EC

UniProtKB Entries (1)

Aspergillus flavus

PDB Structure

PDB 1R56
External Links
Primary Citation
Complexed and ligand-free high-resolution structures of urate oxidase (Uox) from Aspergillus flavus: a reassignment of the active-site binding mode.
Retailleau, P., Colloc'h, N., Vivares, D., Bonnete, F., Castro, B., El-Hajji, M., Mornon, J.P., Monard, G., Prange, T.
Acta Crystallogr.,Sect.D