CATH Domain 1qqgB01

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CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.30	Roll
	2.30.29	PH-domain like
	2.30.29.30	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Domain Context

CATH Clusters

Superfamily	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Functional Family	Insulin receptor substrate 1

Enzyme Information

UniProtKB Entries (1)

IRS1_HUMAN

Homo sapiens

Insulin receptor substrate 1

PDB Structure

PDB	1QQG
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1. Dhe-Paganon, S., Ottinger, E.A., Nolte, R.T., Eck, M.J., Shoelson, S.E. Proc.Natl.Acad.Sci.USA