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CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Shikimate dehydrogenase (NADP(+))

Enzyme Information

1.1.1.25
Shikimate dehydrogenase.
based on mapping to UniProt P15770
Shikimate + NADP(+) = 3-dehydroshikimate + NADPH.
-!- NAD(+) cannot replace NADP(+). -!- In higher organisms, this enzyme forms part of a multienzyme complex with EC 4.2.1.10.

UniProtKB Entries (1)

P15770
AROE_ECOLI
Escherichia coli K-12
Shikimate dehydrogenase (NADP(+))

PDB Structure

PDB 1NYT
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structures of shikimate dehydrogenase AroE and its Paralog YdiB. A common structural framework for different activities.
Michel, G., Roszak, A.W., Sauve, V., Maclean, J., Matte, A., Coggins, J.R., Cygler, M., Lapthorn, A.J.
J.Biol.Chem.
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