CATH Domain 1nstA00

×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Domain Context

CATH Clusters

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family	bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1

Enzyme Information

2.8.2.8	[Heparan sulfate]-glucosamine N-sulfotransferase. based on mapping to UniProt P52848 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine. -!- The enzyme also catalyzes the sulfation of chondroitin 4-sulfate and dermatan sulfate, but to a much more limited extent. -!- Formerly EC 2.8.2.12.
2.8.2.-	Sulfotransferases. based on mapping to UniProt P52848
3.-.-.-	Hydrolases. based on mapping to UniProt P52848

UniProtKB Entries (1)

NDST1_HUMAN

Homo sapiens

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1

PDB Structure

PDB	1NST
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of the sulfotransferase domain of human heparan sulfate N-deacetylase/ N-sulfotransferase 1. Kakuta, Y., Sueyoshi, T., Negishi, M., Pedersen, L.C. J.Biol.Chem.