CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.140.20
Functional Family Bifunctional purine biosynthesis protein PURH

Enzyme Information

3.5.4.10
IMP cyclohydrolase.
based on mapping to UniProt P31335
IMP + H(2)O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
2.1.2.3
Phosphoribosylaminoimidazolecarboxamide formyltransferase.
based on mapping to UniProt P31335
10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide.

UniProtKB Entries (1)

P31335
PUR9_CHICK
Gallus gallus
Bifunctional purine biosynthesis protein PURH

PDB Structure

PDB 1M9N
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural Insights into the Avian AICAR Transformylase Mechanism.
Wolan, D.W., Greasly, S.E., Beardsley, G.P., Wilson, I.A.
Biochemistry