CATH Classification

Domain Context

CATH Clusters

Superfamily Glycosidases
Functional Family Endochitinase B1

Enzyme Information

3.2.1.14
Chitinase.
based on mapping to UniProt P0CB51
Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta- linkages in chitin and chitodextrins.
-!- The enzyme binds to chitin and randomly cleaves glycosidic linkages in chitin and chitodextrins in a non-processive mode, generating chitooligosaccharides and free ends on which exo-chitinases and exo- chitodextrinases can act. -!- Activity is greatly stimulated in the presence of EC 1.14.99.53, which attacks the crystalline structure of chitin and makes the polymer more accesible to the chitinase. -!- Cf. EC 3.2.1.202.

UniProtKB Entries (1)

P0CB51
CHI1_COCPS
Coccidioides posadasii str. Silveira
Endochitinase 1

PDB Structure

PDB 1LL4
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
THE STRUCTURE OF AN ALLOSAMIDIN COMPLEX WITH THE Coccidioides IMMITIS CHITINASE DEFINES A ROLE FOR A SECOND ACID RESIDUE IN SUBSTRATE-ASSISTED MECHANISM
BORTONE, K., MONZINGO, A.F., ERNST, S., ROBERTUS, J.D.
J.Mol.Biol.