CATH Classification

Domain Context

CATH Clusters

Superfamily Nitrogenase molybdenum iron protein domain
Functional Family

Enzyme Information
based on mapping to UniProt P07328
8 reduced ferredoxin + 8 H(+) + N(2) + 16 ATP + 16 H(2)O = 8 oxidized ferredoxin + H(2) + 2 NH(3) + 16 ADP + 16 phosphate.
-!- The enzyme is a complex of two components (namely dinitrogen reducatse and dinitrogenase). -!- Dinitrogen reductase is a [4Fe-4S] protein, which, in the presence of two molecules of ATP, transfers an electron from ferredoxin to the dinitrogenase component. -!- Dinitrogenase is a molybdenum-iron protein that reduces dinitrogen to two molecules of ammonia in three successive two-electron reductions via diazene and hydrazine. -!- The reduction is initiated by formation of hydrogen in stoichiometric amounts. -!- Acetylene is reduced to ethylene (but only very slowly to ethane), azide to nitrogen and ammonia, and cyanide to methane and ammonia. -!- In the absence of a suitable substrate, hydrogen is slowly formed. -!- Ferredoxin may be replaced by flavodoxin (see EC -!- The enzyme does not reduce CO (cf. EC -!- Formerly EC

UniProtKB Entries (1)

Azotobacter vinelandii
Nitrogenase molybdenum-iron protein beta chain

PDB Structure

External Links
Primary Citation
Structure of a cofactor-deficient nitrogenase MoFe protein.
Schmid, B., Ribbe, M.W., Einsle, O., Yoshida, M., Thomas, L.M., Dean, D.R., Rees, D.C., Burgess, B.K.