CATH Classification

Domain Context

CATH Clusters

Superfamily HUPs
Functional Family Nicotinamide-nucleotide adenylyltransferase

Enzyme Information

2.7.7.18
Nicotinate-nucleotide adenylyltransferase.
based on mapping to UniProt Q9HAN9
ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD(+).
2.7.7.1
Nicotinamide-nucleotide adenylyltransferase.
based on mapping to UniProt Q9HAN9
ATP + nicotinamide ribonucleotide = diphosphate + NAD(+).
-!- Nicotinate nucleotide can also act as acceptor. -!- See also EC 2.7.7.18.

UniProtKB Entries (1)

Q9HAN9
NMNA1_HUMAN
Homo sapiens
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

PDB Structure

PDB 1KR2
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of Hhuman of Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurin.
Zhou, T., Kurnasov, O., Tomchick, D.R., Binns, D.D., Grishin, N.V., Marquez, V.E., Osterman, A.L., Zhang, H.
J.Biol.Chem.