CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Cyclopropane mycolic acid synthase 1

Enzyme Information

2.1.1.79
Cyclopropane-fatty-acyl-phospholipid synthase.
based on mapping to UniProt P9WPB7
S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl- L-homocysteine + phospholipid cyclopropane fatty acid.
-!- Adds a methylene group across the 9,10 position of a Delta(9)- olefinic acyl chain in phosphatidylethanolamine or, more slowly, phosphatidylglycerol or phosphatidylinositol forming a cyclopropane derivative (cf. EC 2.1.1.16).

UniProtKB Entries (1)

P9WPB7
CMAS1_MYCTU
Mycobacterium tuberculosis H37Rv
Cyclopropane mycolic acid synthase 1

PDB Structure

PDB 1KPG
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis
Huang, C.-C., Smith, C.V., Glickman, M.S., Jacobs Jr., W.R., Sacchettini, J.C.
J.Biol.Chem.